1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid - Names and Identifiers

Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid
Synonyms	7-azaindole-3-carboxylic ... 7-Azaindole-3-Carboxylic acid 7-AZAINDOLE-3-CARBOXYLIC ACID Methyl 7-azaindole-3-carboxylic acid 1H-pyrrolo[2,3-b]pyridine-3-carbo×ylic acid 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 3-Carboxy-1H-pyrrolo[2,3-b]pyridine
CAS	156270-06-3
InChI	InChI=1/C8H6N2O2/c11-8(12)6-4-10-7-5(6)2-1-3-9-7/h1-4H,(H,9,10)(H,11,12)

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid - Physico-chemical Properties

Molecular Formula	C8H6N2O2
Molar Mass	162.15
Density	1.49±0.1 g/cm3(Predicted)
Melting Point	205-209 °C
Boling Point	425.3±45.0 °C(Predicted)
Flash Point	224.03°C
Water Solubility	Slightly soluble in water.
Vapor Presure	0mmHg at 25°C
Appearance	Solid
pKa	0.52±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.743
MDL	MFCD07778360

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3
HS Code	29339980
Hazard Class	IRRITANT

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic acid - Introduction

1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid is an organic compound with the chemical formula C12H8N2O2.

Nature:
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid is a solid with a white crystalline form. It is a weak acid that can react with a base to form the corresponding salt. The compound is insoluble in water at normal temperature, but soluble in organic solvents such as chloroform, methanol and ethanol.

Use:
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid is widely used as an intermediate in organic synthesis in the fields of medicine, pesticide and dye. It can be used for the synthesis of aminopyrimidine anticancer drugs, trifluoro chloropyrimidine and other drugs.

Method:
1H-Pyrrolo [2,3-b] Pyridine-3-Carboxylic acid has many preparation methods. A common method is through benzopyrrolo [2,3-b] pyridine-3, the 6-diketone is obtained by reaction with formic acid. Specific preparation methods can be found in the literature and chemical handbooks, as required.

Safety Information:
1h-yrrolo [2,3-b] The safety of Pyridine-3-Carboxylic acid is good, but necessary safety protection measures are still needed. Rinse immediately with water when in contact with skin. Wear chemical protective gloves and eye protection equipment when handling this compound. Avoid inhaling its dust or contact with food and drinking water. If necessary, it should be operated in a well-ventilated area to prevent its vapor concentration from exceeding safety standards. When using and storing the compound, it should be handled in accordance with relevant regulations and safe operating procedures.

Last Update：2024-04-09 02:00:42